美国PeproTech公司是全球最大的重组细胞因子和蛋白生产商之一，始终致力于为生命科学研究开发重组蛋白及相关产品，如今已成为能提供多种高质量细胞因子和重组蛋白，相应的单克隆、多克隆和生物素标记抗体，以及ELISA试剂盒的世界领导者。PeproTech.的产品涵盖免疫调节蛋白、白介素、集落刺激因子、生长因子、无动物成分的重组蛋白、化学趋化因子、干扰素、脂联素、成纤维生长因子、转化生长因子、肿瘤坏死因子、神经营养素和防御素等诸多生命科学研究领域中重要的生物活性分子。PeproTech公司的产品种类、规格齐全，更新速度快，且价格适中，已广为中国的科研工作者所使用。

为跟踪当今科研发展、满足日益增长的需求，PeproTech公司追求不断创新和与时俱进。PeproTech公司2015年10月推出3种新产品，分别是：
 

类别	名称	货号	规格	价格(RMB)
细胞因子	重组人/小鼠/大鼠Irisin	100-65	2ug	1000
细胞因子	重组人/小鼠/大鼠Irisin	100-65	10ug	2450
细胞因子	重组人/小鼠/大鼠Irisin	100-65	100ug	15280
细胞因子	重组人/小鼠/大鼠Irisin	100-65	250ug	26750
细胞因子	重组人/小鼠/大鼠Irisin	100-65	500ug	45860
细胞因子	重组人/小鼠/大鼠Irisin	100-65	1000ug	76440
细胞因子	重组人B7-H2 Fc	310-37	1000ug	79800
细胞因子	重组人B7-H2 Fc	310-37	20ug	1000
细胞因子	重组人B7-H2 Fc	310-37	100ug	2450
细胞因子	重组人B7-H2 Fc	310-37	250ug	7270
细胞因子	重组人B7-H2 Fc	310-37	500ug	10510
细胞因子	重组人B7-H2 Fc	310-37	1000ug	16170
细胞因子	重组小鼠RANK Ligand	315-11C	2ug	1000
细胞因子	重组小鼠RANK Ligand	315-11C	10ug	2450
细胞因子	重组小鼠RANK Ligand	315-11C	50ug	11460
细胞因子	重组小鼠RANK Ligand	315-11C	100ug	15280
细胞因子	重组小鼠RANK Ligand	315-11C	250ug	26750
细胞因子	重组小鼠RANK Ligand	315-11C	500ug	45860
细胞因子	重组小鼠RANK Ligand	315-11C	1000ug	76440

 

1. 重组人/小鼠/大鼠Irisin
产品描述：Irisin is a proteolytic hormone released into circulation by skeletal muscle tissue during acute exercise, and is a derivative of the cleaved plasma membrane protein Fibronectin type III domain-containing protein 5 (FNDC5). Found in muscle tissue, FNDC5 is synthesized at increased level during exercise as a result of the overexpression of the exercise-responsive transcriptional co-activator PGC-1α (peroxisome proliferator-activated receptor-γ co-activator-1α). Like its parent polypeptide, Irisin can induce the browning of subcutaneous adipocytes, or the conversion of white adipose tissue (WAT or white fat) into brown (or beige) adipose tissue (BAT or brown fat). Given that brown fat can undergo thermogenesis, or the physiologic process of heat production, Irisin contributes to the metabolic process by increasing thermogenic function and glucose homeostasis. Irisin, thus, represents a link between exercise and “burning” of fats and/or sugars, and consequently may have relevance in the development of new treatments for diabetes and obesity. CHO cell-derived Recombinant Human/Murine/Rat Irisin is a glycosylated homodimer of 224 amino acid residues, whose monomer consists of 112 amino acid residues corresponding to the active portion of the 121-amino-acid length Irisin extracellular domain. Recombinant Human/Murine/Rat Irisin, appears to form a non-disulfide linked oligomeric structure in solution, has a calculated theoretical molecular weight of 25.2 kDa, but migrates at an apparent molecular weight of 28 kDa by SDS-PAGE analysis under reducing conditions due to glycosylation.

2. 重组人B7-H2 Fc

产品描述：B7-H2, or inducible costimulator-ligand (ICOSL), is a transmembrane, co-stimulatory ligand of the T cell-specific surface receptor Inducible T-cell costimulator (ICOS) that belongs to the B7 family and immunoglobulin superfamily, along with B7-1, B7-2 and PD-L1 (B7-H1) and PD-L2. Whereas expression of inducible B7-1 and B7-2 is largely confined to specialized antigen-presenting cells of lymphoid tissues, B7-H2 expression occurs constitutively in hematopoietic and non-hematopoietic cells of peripheral organs. This striking difference in expression indicates that these three B7 ligands may enable temporally and spatially specific regulation of T cell response through non-competitive CD28 interaction; marking a unique function of B7-H2 in immune reactions of nonlymphoid organs in which T cells have migrated to peripheral tissues having only limited expression of B7-1 and B7-2. Expression of B7-H2 has been shown to be differentially regulated by both TNF-α and IL-1β, and inducible to a lesser extent by CD40 or lipopolysaccharide stimulation. B7-H2’s binding to ICOS on activated T cells results in both positive and negative effects on immune response, including its own downregulation. As a member of the immunoglobulin superfamily, B7-H2 is crucially involved in inflammatory immune reactions and the control of excessive immune response; however, unlike B7-1 and B7-2, B7-H2 has not been shown to influence immunity through interaction with CTLA-4, and has only been shown to have restricted interaction with CD28. Interaction of B7-H2 with ICOS has been identified as a critical event in the immunosuppression of tumor-associated memory CD4+ T cells, and has been linked to various auto-immune disorders. PeproTech’s CHO cell-derived Recombinant Human B7-H2 Fc is a glycosylated, disulfide-linked homodimer of 942 amino acid residues whose monomer consists of the 238-amino-acid length extracellular portion of B7-H2 fused to the 231-amino-acid length Fc portion of human IgG1 by two glycines. The calculated molecular weight of Recombinant Human B7-H2 Fc dimer is 104.9 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of approximately 90-95 kDa by SDS-PAGE analysis under reducing conditions.


3. 重组小鼠RANK Ligand

产品描述：RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK + T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant Murine sRANK Ligand is a 19.8 kDa polypeptide comprising the TNF-homologous region of RANKL (178 amino acid residues).


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PeproTech(派普泰克)中国代表处
江苏省苏州市玉山路99号钻石广场2幢416室
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