派普泰克生物科技（苏州）有限公司（PeproTech中国）

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公司新闻

PeproTech 2020年8月发布Murine BRAK (CXCL14) （250-45）、Murine GPR15L (300-72)、Human Tissue Factor (150-19T) 3种新品！

发布时间：2021-11-11 15:38 |  点击次数：

     

 
美国PeproTech公司是全球最大的重组细胞因子和蛋白生产商之一，始终致力于为生命科学研究开发重组蛋白及相关产品，如今已成为能提供多种高质量细胞因子和重组蛋白，相应的单克隆、多克隆和生物素标记抗体，以及ELISA试剂盒的引领者。PeproTech.的产品涵盖免疫调节蛋白、白介素、集落刺激因子、生长因子、无动物成分的重组蛋白、化学趋化因子、干扰素、脂联素、成纤维生长因子、转化生长因子、肿瘤坏死因子、神经营养素和防御素等诸多生命科学研究领域中重要的生物活性分子。PeproTech公司的产品种类、规格齐全，更新速度快，且价格适中，已广为中国的科研工作者所使用。
     
 
      为跟踪当今科研发展、满足日益增长的需求，PeproTech公司追求不断创新和与时俱进。PeproTech公司2020年1月推出3种新产品：Murine BRAK (CXCL14) （250-45）、Murine GPR15L (300-72)、Human Tissue Factor (150-19T) ，其中150-19停产，库存售完为止，由150-19T替代，另外PeproGMP® Recombinant Human IL-21 （GMP200-21）新增了100ug规格。详情如下：
 
类别 名称 货号 规格 价格/RMB
细胞因子 Murine GPR15L 300-72-5 5ug ¥1,050 
细胞因子 Murine GPR15L 300-72-25 25ug ¥2,570 
细胞因子 Murine GPR15L 300-72-100 100ug ¥9,240 
细胞因子 Murine GPR15L 300-72-250 250ug ¥16,170 
细胞因子 Murine GPR15L 300-72-500 500ug ¥27,720 
细胞因子 Murine GPR15L 300-72-1000 1mg ¥46,200 
细胞因子 Human Tissue Factor 150-19T-2 2ug ￥1,050 
细胞因子 Human Tissue Factor 150-19T-10 10ug ￥2,570 
细胞因子 Human Tissue Factor 150-19T-50 50ug ￥9,600 
细胞因子 Human Tissue Factor 150-19T-100 100ug ￥16,010 
细胞因子 Human Tissue Factor 150-19T-250 250ug ￥28,020 
细胞因子 Human Tissue Factor 150-19T-500 500ug ￥48,040 
细胞因子 Human Tissue Factor 150-19T-1000 1mg ￥80,080 
细胞因子 Murine BRAK (CXCL14) 250-45-5 5ug ¥1,050 
细胞因子 Murine BRAK (CXCL14) 250-45-20 20ug ¥2,570 
细胞因子 Murine BRAK (CXCL14) 250-45-100 100ug ¥9,240 
细胞因子 Murine BRAK (CXCL14) 250-45-250 250ug ¥16,170 
细胞因子 Murine BRAK (CXCL14) 250-45-500 500ug ¥27,720 
细胞因子 Murine BRAK (CXCL14) 250-45-1000 1mg ¥46,200 
GMP级别细胞因子 PeproGMP® Recombinant Human IL-21 GMP200-21-100 100ug ￥37,400 

1.重组小鼠 GPR15L
产品描述:GPR15L is a newly identified ligand for GPR15, a member of the G protein‐coupled receptor (GPCR) family. Upon ligation, GPR15L acts as a potent chemoattractant for GPR15‐expressing T cells and together they mediate lymphocyte recruitment to the large intestine and skin. GPR15L is constitutively expressed by colon epithelial cells where its expression is minimally altered by intestinal inflammation. Conversely, GPR15L is nearly undetectable in adult epidermis but highly upregulated during wound healing and inflammation, particularly in psoriasis. Significant expression of GPR15L is also seen in additional mucosal epithelial cells, including those of the stomach, esophagus, and urinary tract. While maintaining similar expression patterns and intramolecular disulfide cysteine bridges found in members of the CC chemokine family, GPR15L differs from classic CC and CXC chemokines, whose active sites are found on the N‐terminus, in that it relies on its C‐terminus for receptor interaction. GPR15L was first identified as an antimicrobial peptide (AMP) due to its broad spectrum of antimicrobial activity, a property shared with many chemokines. GPR15L binds to an additional receptor, SUSD2, and early studies have indicated that both are downregulated in colon cancer tissue resulting in inhibited colon cancer growth. PeproTech’s E.coli‐derived Recombinant Murine GPR15L consists of 54 amino acid residues and has a calculated molecular weight of 6.3 kDa.

2.重组人Tissue Factor
产品描述:Tissue factor is a transmembrane glycoprotein of the cytokine receptor superfamily that acts as a receptor for coagulation factor VII (fVII) to trigger initiation of the coagulation cascade in response to vascular injury. Expression of tissue factor occurs constitutively within most extravascular and perivascular cells and at high levels within critical organs and tissue. Tissue factor is not normally expressed freely on the surface of circulating blood cells due to its pro‐coagulant effect, but is instead stored on the surface of mononuclear and endothelial cells in microparticles that can shed into circulation in response to vascular injury, pro‐inflammatory cytokines, or microbial ligands. Tissue factor can also be shed into circulation by cancer cells where its expression in a number of cancer types has been linked to tumor progression, metastatic potential, thrombosis, and angiogenesis. Expression of tissue factor has been shown to be inducible by select cytokines in a number of cell types, including
IL‐1β and TNF‐α in vascular endothelial cells and macrophages, and TNF‐α, IL‐6, and FGF‐Basic in monocytes, among others. PeproTech’s CHO cell‐derived Recombinant Human Tissue Factor is a glycoprotein homodimer comprised of the 227‐amino‐acid length monomer containing a C‐terminal His‐Tag. It has a calculated molecular weight of approximately 25.8 kDa, and as a result of glycosylation, Recombinant Human Tissue Factor migrates with an apparent molecular mass of approximately 40‐50 kDa by SDS‐PAGE gel.

3.重组小鼠BRAK (CXCL14)
产品描述:Breast and Kidney‐expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP‐2 α and β. Recombinant Murine BRAK (CXCL14) is a 9.4 kDa protein containing 77 amino acid residues.

4.GMP级别重组人IL-21
产品描述:IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. Recombinant Human IL-21 is a 15.4 kDa protein consisting of 132 amino acid residues.