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PeproTech 2018年11月发布Human C5a、Human Epiregulin、Human BTLA Fc等8新品！
发布时间：2018-11-02 16:02 | 点击次数：
美国PeproTech公司是全球最大的重组细胞因子和蛋白生产商之一，始终致力于为生命科学研究开发重组蛋白及相关产品，如今已成为能提供多种高质量细胞因子和重组蛋白，相应的单克隆、多克隆和生物素标记抗体，以及ELISA试剂盒的引领者。PeproTech.的产品涵盖免疫调节蛋白、白介素、集落刺激因子、生长因子、无动物成分的重组蛋白、化学趋化因子、干扰素、脂联素、成纤维生长因子、转化生长因子、肿瘤坏死因子、神经营养素和防御素等诸多生命科学研究领域中重要的生物活性分子。PeproTech公司的产品种类、规格齐全，更新速度快，且价格适中，已广为中国的科研工作者所使用。
产品描述:Complement 5a (C5a) is an enzymatically generated glycoprotein belonging to the anaphylatoxin family of structurally and functionally related proteins. Generated upon the activation of the complement system, C5a, together with C4a, C3a, and the membrane attack complex (C5b-9), functions as a central player in host defense by inducing smooth muscle cell contraction, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes through cell degranulation. In addition to acting as a direct mediator of localized inflammatory response, C5a also initiates both the synthesis and release of IL-8 from monocytes and bronchial epithelial cells, stimulates the proliferation of neurons and hepatocytes, and functions as a potent chemoattractant. Where C5a deficiency, a rare defect of the complement pathway caused by the mutation of the C5a gene, is associated with susceptibility to severe infections, excessive C5a activation has been linked to liver fibrosis, sepsis, adult respiratory distress syndrome, rheumatoid arthritis, Alzheimer’s disease, and ischemic heart disease. Human C5a shares 60% and 54% sequence identity to mouse and rat C5a, respectively. The human C5 gene encodes a 1,676 amino acid glycoprotein that is comprised of a disulfide-linked C5 alpha and a C5 beta chain, the former of which contains the active, 74 amino acid C5a anaphylatoxin chain. Recombinant Human C5a is an 8.28 kDa glycoprotein containing the 74 amino acid residues of the C5a anaphylatoxin chain. 2.无动物成份重组人Epiregulin 产品描述:Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence. Recombinant Human Epiregulin is a 5.6 kDa monomeric protein, containing 50 amino residues, which corresponds to the mature secreted Epiregulin sequence. 3.兔抗人Uteroglobin（生物素标记） 产品描述:Produced from sera of rabbits immunized with highly pure Recombinant Human Uteroglobin. Anti-Human Uteroglobin-specific antibody was purified by affinity chromatography and then biotinylated. 4.小鼠抗人CRP单抗 产品描述：Produced in BALB/c mice immunized with highly pure Recombinant Human CRP. Anti-Human CRP-specific antibody was purified from cell culture supernatant by Protein A affinity chromatography. 5.兔抗人Uteroglobin多抗 产品描述：Produced from sera of rabbits immunized with highly pure Recombinant Human Uteroglobin. Anti-Human Uteroglobin-specific antibody was purified by affinity chromatography employing an immobilized Human Uteroglobin matrix. 6.重组人BTLA Fc 产品描述:B- and T-lymphocyte attenuator (BTLA), or CD272, is a type I transmembrane co-inhibitory receptor of the CD28 receptor family that is involved in modulating adaptive immune responses and T cell co-stimulation. BTLA acts in a manner similar to PD-1 and CTLA-4, the other inhibitory receptors of the CD28 family, as an anti-inflammatory molecule crucial to dampening immune response. Expressed most prominently in T cells, including Th1, Th2, CD4+, and CD8+ cells, BTLA can also be found in B cells, NK cells, dendritic cells and macrophages. Ligation of BTLA with HVEM, a member of the TNF receptor super family (TNFRSF), induces tyrosine phosphorylation of ITIM and ITSM motifs found within the BTLA cytoplasmic domain, resulting in association with SHP-1 and SHP-2. While HVEM’s interactions with the ligands LIGHT and Lymphotoxin-α induce a powerful stimulatory immune response, the interaction of BTLA and HVEM attenuates T cell proliferation and the production of cytokines including IL-2, IL-10 and IFN-γ. This interaction between BTLA and HVEM is the only receptor-ligand interaction known to bridge the CD28 and TNFR families. Recent studies provide evidence that engagement of BTLA’s third cytoplasmic motif, Grb2, may transmit a positive signal, suggesting both a co-inhibitory and co-stimulatory role for BTLA. Dysfunction of the BTLA pathway plays a role in the pathogenesis of numerous autoimmune diseases and cancers.--The naturally occurring human BTLA monomer consists of a 127-amino-acid extracellular domain, a 21-amino-acid transmembrane domain, and a 111-amino-acid cytoplasmic domain. PeproTech’s CHO cell-derived Recombinant Human BTLA Fc is a glycosylated, disulfide-linked homodimer of 353-amino-acid-residues whose monomer consists of a 120-amino-acid portion of the extracellular domain fused to the 231-amino-acid length Fc portion of human IgG by two glycine residues. The calculated molecular weight of monomeric CHO cell-derived Recombinant Human BTLA Fc is 39.8 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of approximately 50-55 kDa by SDS-PAGE analysis under reducing conditions. 7.重组小鼠Murine Prokineticin-2 产品描述:Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the testis and, in lower levels, in the small intestine. PK2 regulates various biological functions, including gastrointestinal motility, angiogenesis and circadian rhythms. It is closely related to EG-VEGF (Prokineticin-1), and binds to two orphan B-protein-coupled receptors termed PK-R1 and PK-R2. Recombinant Murine Prokineticin-2 is an 11.6 kDa protein consisting of 103 amino acid residues, including ten cysteine residues that can potentially form five pairs of intra-molecular disulfide bonds. 8.重组人VEGF-C 产品描述: VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated, non-covalent, disulfide-linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant Human VEGF-C is a disulfide-linked homodimeric protein consisting of two 13.5 kDa polypeptide chains of 116 amino acid residues. Due to glycosylation, the protein migrates as a 30.0-33.0 kDa band by SDS-PAGE analysis under non-reducing conditions. *As of January 30, 2019 Human VEGF-C (Catalog Number 100-20CD) will be replacing Human VEGF-C (Catalog Number 100-20C 欢迎各位科研工作者前来咨询和订购！ PeproTech将继续支持您的科研工作，祝您工作顺利！ PeproTech(派普泰克)中国代表处 江苏省苏州市玉山路99号钻石广场2幢416室 邮编：215011 电话：0512-6832 5983 全国免费热线：4000053055 企业qq:800053055(在线咨询) Email：china@peprotech.com Website：www.peprotech.com |